San Pasqual Valley is the northernmost community of the city of San Diego. It is named for the Kumeyaay village of San Pasqual that was once located there. It is bordered on the north by the city of Escondido, on the east and west by unincorporated land within San Diego County, and on the south by the city of Poway and the community of Rancho Bernardo. San Pasqual Valley is home to the San Diego Zoo Safari Park.

State Highway 78 runs through the valley between Escondido and Ramona. The valley is part of the Santa Ysabel Creek watershed, which drains into the San Dieguito River.